Kicking the Epicardium Up a Notch

Kicking the epicardium up a notch.

The epicardium is a layer of fibrous mesothelium that covers the external surface of the heart. Until recently, the main function of this tissue was thought to be protective and to contribute to production of pericardial fluid. Recently, however, renewed interest in the function of the epicardium has identified important contributions to cardiac development, disease, and regeneration. In the de...

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Reprogramming the Beat Kicking It Up a Notch Sean

The explosion of stem cell research in cardiology has yielded an increasing recognition that understanding developmental cell fate decisions is critical for everything from disease models to cellular therapeutics. However, the biology is particularly rich and complex and has not yielded easily to traditional investigative methods. One area of intense focus is the study of the cues responsible f...

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Reprogramming the beat: kicking it up a notch.

The explosion of stem cell research in cardiology has yielded an increasing recognition that understanding developmental cell fate decisions is critical for everything from disease models to cellular therapeutics. However, the biology is particularly rich and complex and has not yielded easily to traditional investigative methods. One area of intense focus is the study of the cues responsible f...

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Editorial Reprogramming the Beat Kicking It Up a Notch Sean

The explosion of stem cell research in cardiology has yielded an increasing recognition that understanding developmental cell fate decisions is critical for everything from disease models to cellular therapeutics. However, the biology is particularly rich and complex and has not yielded easily to traditional investigative methods. One area of intense focus is the study of the cues responsible f...

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Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.

RATIONALE The embryonic epicardium plays a crucial role in the formation of the coronary vasculature and in myocardial development, yet the exact contribution of epicardium-derived cells (EPDCs) to the vascular and connective tissue of the heart, and the factors that regulate epicardial differentiation, are insufficiently understood. OBJECTIVE To define the role of Notch signaling in murine e...

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Kicking the Epicardium Up a Notch

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